5-HTP

5-HTP Organic 100 mg (60 Capsules)

Description:

5-HTP (5-Hydroxytryptophan) is a naturally occurring amino acid derivative and an intermediate in serotonin biosynthesis. Extracted from the seeds of Griffonia simplicifolia, it supports emotional well-being, stress management, and better sleep. Enhanced with Vitamin B6, this formula optimizes serotonin production, addressing mood irregularities and promoting relaxation.

Mechanism of Action:

5-HTP is absorbed in the gastrointestinal tract and converted in the liver to serotonin via the enzyme aromatic L-amino acid decarboxylase, a reaction dependent on Vitamin B6 as a cofactor. After conversion, serotonin cannot cross the blood-brain barrier, but 5-HTP can. Once in the brain, 5-HTP undergoes further conversion to serotonin, supporting neurotransmitter balance essential for mood, appetite regulation, and circadian rhythm stabilization.

Pharmacokinetics:

• Absorption: 5-HTP is rapidly absorbed after oral administration, with bioavailability exceeding 70%.
• Distribution: It crosses the blood-brain barrier efficiently due to its lipophilic nature.
• Metabolism: In the liver, 5-HTP is hydroxylated into serotonin, and excess serotonin is metabolized to 5-HIAA (5-hydroxyindoleacetic acid) for excretion.
• Excretion: Metabolites are eliminated primarily via the kidneys.

Ingredients:

• 5-Hydroxytryptophan (5-HTP) – 100 mg
• Vitamin B6 – 2 mg
• Microcrystalline cellulose, gelatin capsule, titanium dioxide.

Indications for Use:

• Enhancing mood and reducing symptoms of mild depression
• Supporting deeper, restorative sleep cycles
• Managing stress and improving emotional resilience
• Appetite regulation for individuals with cravings

Pros:

• Effective natural serotonin booster
• Non-habit forming alternative to synthetic mood stabilizers
• May help reduce symptoms of insomnia

Cons:

• Potential for mild nausea or digestive upset in sensitive individuals
• Interaction risks with medications affecting serotonin pathways

Precautions:

• Avoid use with SSRIs, MAO inhibitors, or other serotonergic drugs to prevent serotonin syndrome.
• Not recommended for use in pregnancy, lactation, or by individuals with severe mood disorders without medical advice.

Contraindications:

• Known hypersensitivity to components of the supplement
• Pre-existing gastrointestinal conditions or compromised liver function

Recommended Dose:

Take 1 capsule daily with food or as directed by a healthcare provider.